Comparative evaluation of antiulcer activity of combination of extracts of Embilica officinalis Gaertn and Musa sapientum Linn in rats

  • Keserla Bhavani Department of Pharmacology, Krupanidhi College of Pharmacy, Bangalore 560035, Karnataka, India
  • Gnanavel V Department of Pharmaceutical Chemistry, Krupanidhi College of Pharmacy, Bangalore 560035, Karnataka, India
  • Ratna B Department of Pharmacology, Krupanidhi College of Pharmacy, Bangalore 560035, Karnataka, India
  • Jayakar B Department of Pharmacology, Vinayaka Missions University, Salem 636008 Tamil Nadu, India
  • Aanandan Department of Pharmacology, Vinayaka Missions University, Salem 636008 Tamil Nadu, India
  • Natukula Praveen Kumar Department of Pharmaceutical Analysis, Mylan Laboratories, Hosur 635109 Tamil Nadu, India
  • Koya Prabhakar Rao Department of Pharmaceutical Analysis, Vignan University, Vadlamudi 522213 Andhra Pradesh, India
  • Namburi Lakshmi Anjaneya Amarbabu Department of Pharmaceutical Analysis, Vignan University, Vadlamudi 522213 Andhra Pradesh, India

Abstract

The present study is to evaluate the anti-ulcer activity of methanolic extract of unripe fruits of Musa Sapientum Linn. and the fresh juice of the fruits of Emblica Officinalis Gaertn in Wistar rats. The methanolic extract unripened fruits of Musa Sapientum Linn.  and the fresh juice of the fruits of Emblica Officinalis Gaertn were combined and evaluated for the gastroprotective activity by ethanol-induced model and indomethacin-induced model in rats at a dose of 25mg/kg (p.o) and 50mg/kg (p.o) respectively. Biochemical parameters like ulcer index, the volume of gastric juice, pH of gastric juice, free acidity and total acidity were studied. The unripe fruits of Musa and the fresh juice of Embilica will contain flavonoids, flavones, abscisic acid which shows a significant reduction in gastric volume, pH, free acidity, total acidity and ulcer index at the doses of 25mg/kg (p.o) and 50mg/kg (p.o). The results show that the unripe fruits 0f Musa Sapientum Linn. and fresh juice from the fruits of Emblica Officinalis Gaertn will combinedly possess greater antiulcer activity than that of the individual drugs.

Keywords: Gastroprotective, Ethanol-induced ulcers, Indomethacin-induced ulcers, Gastric acidity, Ulcer index

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Published
2019-04-23
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Keserla Bhavani, Gnanavel V, Ratna B, Jayakar B, Aanandan, Natukula Praveen Kumar, Koya Prabhakar Rao, & Namburi Lakshmi Anjaneya Amarbabu. (2019). Comparative evaluation of antiulcer activity of combination of extracts of Embilica officinalis Gaertn and Musa sapientum Linn in rats. International Journal of Research in Pharmaceutical Sciences, 10(2), 1535-1539. https://doi.org/10.26452/ijrps.v10i2.821
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