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This study was carried out to synthesise some new Schiff bases compounds through condensation of ascorbic acid (keto form) with some compounds which have amine group in their structure also these compounds synthesized by using of microwave irradiation and traditional method and compare the results obtained. Microwave irradiation of organic reactions has quickly acquired popularity as it increases the speed of the reaction towards multiple kinds of synthetic transformations, solventless procedures without the use of supporting reagents and therefore eco-friendly, the antioxidant properties were studied for all compounds included in this study, the results indicate that IC50 for the compounds synthesized by using of microwave irradiation method were higher than the traditional method, and also the biological activity of the prepared compounds were also studied to estimate capability of suppressing Enterococcus, Staphyllo coccus aureus and E. Coli than the starting materials that have biological activity on these bacteria. This study shows that the diameters of inhibitions in Petri dishes have higher and wider at a concentration (10 mg / ml) for used bacteria.
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