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Staphylococci spp has been reported as a major cause of hospital and community-associated infections. Staphylococcus aureus is the most common pathogen causing a variety of infections relatively begins minor skin in sections (abscess. cellulitis, staphylococcal scalded skin syndrome) to live threating systemic infections like endocarditis, septic arthritis, pneumonia joint, and bone infections, toxic shock syndrome. Methicillin resistance was reported in 1961 and emerged in the last several decades as one of the most important nosocomial pathogens which were reported just one year of the launch of methicillin. MRSA now a day a big problem is because it is creating life threating problems medical institutions. The knowledge of MRSA prevalence and current antibiogram profile is necessary for the selection of appropriate treatment for related infections. Isolation and identification of Staphylococcus aureus were done by standard conventional microbiological methods. The Methicillin-resistant Staphylococcus aureus strains were tested by using Cefoxitin 30μg disc on Mueller - Hinton agar and antibiotic susceptibility testing were done by Kirby-Bauer disc diffusion method according to Clinical and Laboratory Standards Insititute guidelines (CLSI). All the 164 MRSA (100%) strains were sensitive to Tigecycline, Vancomycin, Teicoplanin followed by Linezolid (92. 68%). Tigecycline, Vancomycin, Teicoplanin has until now excellent activity against clinical isolates of Methicillin-resistant Staphylococcus aureus.
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