Spectrophotometric method for the determination of benzocaine by cerium ammonium sulphate with promethazine hydrochloride in pure and phar-maceuticals preparation

  • Amal H. Mhemeed College of Pharmacy, Misan University, Amarah, Iraq

Abstract

Easy, the accurate, sensitive spectrophotometric method used to determine Benzocaine in a pure and pharmaceutical preparation. The proposed method depends on using Promethazine hydrochloride as a reagent. Where it depends on oxidative coupling reaction of benzocaine by cerium ammonium sulphate with promethazine hydrochloride in the presence of hydrochloric acid to form green dye product, lmax 615 nm. Beers law is obeyed in the concentration of (5 –300 µg.ml-1). The molar absorptivity is (1.77 * 10 3) L.mol -1.cm-1, a sandal sensitivity of (0.0098) µq.cm-2 and RSD (± 0.56 %). The method gave a successful determination for benzocaine in a pharmaceutical preparation.

Keywords: Benzocaine drug, Promethazine hydro-chloride, Pharmaceutical preparation

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Published
2019-04-23
Citations
How to Cite
Amal H. Mhemeed. (2019). Spectrophotometric method for the determination of benzocaine by cerium ammonium sulphate with promethazine hydrochloride in pure and phar-maceuticals preparation. International Journal of Research in Pharmaceutical Sciences, 10(2), 1420-1423. https://doi.org/10.26452/ijrps.v10i2.707
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Original Articles
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