Memory enhancing effect of Nelumbo nucifera seedpod extract and its active component quercetin in noise stress-exposed rats

  • Ruvanthika PN Research Scholar, Bharath University, Bharath Institute of Higher Education and Research, 173, Agaram Main Road, Selaiyur, Chennai - 600 073, Tamil Nadu, India
  • Manikandan S Department of Physiology, Tagore Medical College and Hospitals, Affiliated to TN Dr MGR Medical University, Guindy, Chennai, Tamil Nadu, India
  • Vishnu Priya V Department of Biochemistry, Saveetha Dental College & Hospitals, Saveetha Institute of Medical & Technical Sciences, Saveetha University, Chennai – 600 077, Tamil Nadu, India

Abstract

Stress is an unavoidable phenomenon which disturbs the physiological homeostasis. Noise is the highest encountered stressor that affects the well-being of mankind. Hippocampus, a region of the brain crucial for memory is highly influenced by stress and thereby deteriorates memory. Male albino Wistar rats of 11-12 weeks were used in this study. Nelumbo nucifera (NNE) 400 mg/kg body weight (BW) and its active principle Quercetin (QRCT) (40 mg/kg bw) were administered orally to the animals 10 days before noise stress exposure of (100dB 4h/d). Ability to retain information by Learning and spatial memory was assessed using eight-arm radial maze apparatus. It was observed that after noise stress exposure errors in working, reference memory and time period to move into all baited arms were increased; however, the drug pre-treated animals showed a decrease in all the above parameters. The observations in the present work have proved that NNE and QRCT groups were effective in ameliorating the noise stress-induced changes, but the active component quercetin group had a higher protective impact on the changes.

Keywords: Nelumbo nucifera, Quercetin, Spatial memory, Noise stress, Corticosterone

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Published
2019-04-16
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How to Cite
Ruvanthika PN, Manikandan S, & Vishnu Priya V. (2019). Memory enhancing effect of Nelumbo nucifera seedpod extract and its active component quercetin in noise stress-exposed rats . International Journal of Research in Pharmaceutical Sciences, 10(2), 1410-1415. https://doi.org/10.26452/ijrps.v10i2.706
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Original Articles
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