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Abstract

The mutagenicity and genotoxicity of sumicidin insecticide 30 EC, which is classified as a synthetic pyrethroid w 30 studied using mitotic index (MI) and chromosomal aberration (CA) in somatic cells (bone marrow and spleen) and male germ cells of rabbits. Sumicidin was administered orally at dose level (2 X 10-5, 2.5 X 10-5, 3 X 10-5M) and control dose level of mitomycin C. Result show that high doses of sumicidin cause a significant reduction in MI and a significant increase in CA for all tissues. Reduction in MI level was significantly higher (p<0.01) in bone marrow and male germ cells than spleen while there is a significant increase in CA level in male germ cells, compared with somatic cells. These results indicate that sumicidin 30 EC is potentially genotoxic in rabbits.

Keywords

Genetics Pyrethroid Lab rabbits Sumicidin Bone marrow

Article Details

How to Cite
Eqbal Dohan Chalap, Farah Safaa Abdulhussein, & Dhuha Salman Asker Aljuboory. (2019). The cellular genetics effect of pyrethroid on lab rabbits. International Journal of Research in Pharmaceutical Sciences, 10(1), 415-418. Retrieved from https://pharmascope.org/ijrps/article/view/70