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The present investigation includes the preparation of liquid filling formulations for soft gels using an anti-migraine drug Sumatriptan Succinate (SMT), in order to improve its rate of absorption and thereby its bioavailability. Formulations were prepared using excipients like polyethylene glycol (PEG-400), propylene glycol (PG), Polyvinylpyrrolidone (PVP K-30), antioxidants, tween-80, SLS, ethanol and purified water. Prepared formulations were evaluated for appearance, pH, drug content uniformity, drug- excipients compatibility, viscosity, and stability and in-vitro dissolution studies. The compatibility between the drug and excipients in the formulations was confirmed by FTIR spectra and DSC thermograms. The drug contents were in the range of 97.65 to 99.62 and the viscosity was in the range of 37.95 to 452.93 cps for all the developed formulations. Formulation F1 containing PEG-400 (20%)/PG (20%)/water (52%) system gave superior drug release when compared to other liquid filling formulations and complete drug release (100%) was observed at the end of 90 seconds. Stability studies were conducted for all formulations (F1-F10) over a period of 6 months at room temperature (30ºC/65%RH). From these studies, it can be concluded that SMT liquid fill formulations for soft gels were successfully prepared. The in-vitro dissolution properties of SMT liquid fill formulations for soft gels were superior when compared to pure SMT and marketed SMT.


Anti-migraine Liquid fill formulations Polyethylene glycol (PEG-400) Propylene glycol (PG) Polyvinylpyrrolidone (PVP K-30) Sumatriptan Succinate Soft gels Tween 80

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How to Cite
Venkat Vardhan Reddy K, & Devineni Jyothirmayee. (2014). Development of immediate release liquid fill formulations for soft gels of sumatriptan succinate. International Journal of Research in Pharmaceutical Sciences, 5(4), 262-269. Retrieved from