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A rapid and accurate high performance reverse phase liquid chromatography has been developed for the simultaneous estimation of Rabeprazole and Domperidone in pharmaceutical dosage forms. Chromatography was carried out on a C-18 column (4.6 mm × 150 mm, 5 μm) using a mixture of phosphate buffer (pH 7.4) and acetonitrile in the ratio of 60:40 (v/v) as the mobile phase at a flow rate of 1.5 mL/min and eluents are monitored at 287 nm. The calibration curves were linear over the range of 0.1 – 1.0 mg/mL of Rabeprazole. The average retention time of Rabeprazole and Domperidone was found to be 3.33 and 5.74 min respectively. The % recovery value for Rabeprazole is 100.2% and for Domperidone is 102% confirms the non-interferences of the excipients in the formulation. Due to its simplicity, rapidness and high precision, the proposed HPLC method may be used for the simultaneous estimation of these two drugs in pharmaceutical dosage forms.
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