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Acute musculoskeletal pain is an illness of muscle, bone, joint, and muscle tissue that is caused by an injury or inflammation. Ibuprofen and Ketorolac are Non-Steroid Anti-Inflammatory Drugs or NSAID that are usually used for non-specific acute musculoskeletal pain. The purpose of the study is to compare the pain relief of non-specific acute musculoskeletal pain between intravenous Ibuprofen and intravenous Ketorolac therapy. This study uses a quasi-experimental, non-randomized, non-equivalent, active comparator, open-label study. The total sample for this study is 60 subjects, divided into two groups (n-30), subjects are required by using purposive sampling. Pain measured by Numeric Pain Scale. The mean baseline of the pain intensity were 63.33 ± 8.841 for the Ibuprofen group and 59.33 ± 12.847 for the Ketorolac group. There was not any differences between both of group (p = 0.107) after the medication were given all measurement shows significant differences between two groups (p = <0.05) that Ibuprofen group shows better results. Intravenous Ibuprofen has better effectivity rather than intravenous Ketorolac as a treatment of non-specific acute musculoskeletal pain.
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