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The effects of extracts of orange, , lime, citron and sour orange fruit peels (250 and 500 mg kg-1, i.p) were tested in high fat diet-fed rats. The extracts of lime and sour orange peels (250 and 500 mg kg-1, i.p) showed potent effects, as evident by the decreases in total cholesterol (TC), triglycerides (TG), LDL-C, and VLDL-C, in addition to the increases in HDL-C levels. Besides, lime and sour orange peels (250 and 500 mg kg-1) extract significantly decreased LDL-C/HDL-C ratio, while lime, sour orange and peel extracts markedly decreased index. Remarkably, lime peel extract followed by sour orange and orange at 500 mg kg-1 improved hepatic architecture to near normal with less deposition of fat globules and fewer. Altogether, lime and sour orange peel extracts were found to be effective against parameters such as TC, TG, LDL-C, VLDL-C, and TC/HDL-C and LDL-C/HDL-C ratios, and index, in addition to the increased levels of HDL-C. Thus, lime and sour orange peel extracts could be natural supplement in the management of and associated diseases.
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