Main Article Content
The heterocyclic aromatic compound benzimidazole is made up of benzene and an imidazole ring. In medicinal chemistry, it's a crucial pharmacophore and a privileged structure. It's a component of the vitamin cobalamin. Antimicrobial, antiviral, antidiabetic, anti-cancer, anti-helminthic, antioxidant, anti-fungal, anti-allergic, anti-parasitic, anti-proliferative, anti-HIV, anti-convulsant, anti-inflammatory, anti-hypertensive and proton pump inhibitors are only a few of the pharmacological functions of benzimidazole derivatives play a critical role throughout the medical sector. The Mannich reaction is one of the most versatile reaction in organic synthesis. This reaction can be used to make N-methyl derivatives and a variety of drug molecules. Mannich base benzimidazole derivatives play a significant role in medicine, with several medicinal applications including antibacterial, anthelmintic, antifungal, anti-inflammatory, antiviral, analgesic and anti-convulsant. Changes in their composition have provided a high degree of variety, which has been beneficial in the case of new therapeutic agents with increased efficacy and lower toxicity. This analysis emphasises the significance of synthesis and various biological activities of newly synthesized mannich bases of benzimidazole derivatives, as well as a few key synthesis methodologies.
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