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This research investigates Staphylococcus aureus pneumonia in mice by oral injection. Infection rate (65%) of histopathological testing reveals a number of changes like the inflammation that is expressed by polymorphonuclear leukocytes. This bacterium is typically responsible for a lung infection. Inflammatory reactions resulted from this infection may cause catching the infection of the lungs like increased neutrophilic inflammation and vascular leakage of serum proteins into the lung to name a few. This study suggests that Staphylokinase production may be a typical virulence factor by means of Staphylococcus aureus that inhabit and lead to fibrinolysis and invasive infections.