Deciphering the Cytotoxic Activity of Annona squamosa Iron Oxide Nanoparticles against selective Cancer Cell Line

  • S Mohanasundaram Department of Biotechnology, Karpaga Vinayaga College of Engineering and Technology, Maduranthagam-603308, Kanchipuram-Dist, Tamilnadu, India.
  • S Hemalatha Department of Biochemistry, School of Life Sciences, Vels University, Pallavaram, Chennai-117, Tamil Nadu, In-dia
  • V Vanitha Department of Biochemistry, School of Life Sciences, Vels University, Pallavaram, Chennai-117, Tamil Nadu, In-dia
  • N Pushpa Bharathi Department of Biotechnology, Karpaga Vinayaga College of Engineering and Technology, Maduranthagam-603308, Kanchipuram-Dist, Tamil Nadu, India
  • M Jayalakshmi Department of Biotechnology, Karpaga Vinayaga College of Engineering and Technology, Maduranthagam-603308, Kanchipuram-Dist, Tamil Nadu, India
  • N Pushpabharathi Department of Biochemistry, School of Life Sciences, Vels University, Pallavaram, Chennai-117, Tamil Nadu, In-dia

Abstract

Annona squamosa is a fruit bearing plant possesses potent bioactive compounds in all its part. In this present investigation, iron oxide nanoparticle was synthesised from a hydroethanolic extract of Annona squamosa leaves at 600 c temperature.  Production of iron oxide nanoparticles in extraction is detected by UV–Visible spectrophotometer between 300 to 700 nm. Scanning electron microscopy was employed to analyse the structure of nanoparticles. Fourier transform infrared spectroscopy (FT-IR) analysis were performed, in order to determine the functional groups on Annona squamosa leaves extract and predict their role in the synthesis of iron oxide nanoparticles. Further, synthesised Fe3O4 NPs shows potential cytotoxicity against liver carcinoma cell line (HepG2) and melanoma (A375) cell line. At the same time, Fe3O4 NPs subjected on the normal Chang liver cell line shows no toxicity. Our report confirmed that the Annona squamosa leaf is a very good eco-friendly and nontoxic bio-reductant for the synthesis of Iron oxide nanoparticle and opens up further opportunities for fabrication of drugs towards cancer therapy.

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Published
2017-07-05
How to Cite
MOHANASUNDARAM, S et al. Deciphering the Cytotoxic Activity of Annona squamosa Iron Oxide Nanoparticles against selective Cancer Cell Line. International Journal of Research in Pharmaceutical Sciences, [S.l.], v. 8, n. 2, p. 259-263, july 2017. ISSN 0975-7538. Available at: <https://www.pharmascope.org/index.php/ijrps/article/view/425>. Date accessed: 21 july 2017.
Section
Research Articles
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