Protective role of eclipta alba against hyperlipidemia induced by high-fat diet in albino rats

  • Satheesh Naik K Research Scholar, Department of Anatomy, Bharath Institute of Higher Education and Research (Bharath University), Chennai, Tamilnadu, India
  • Gurushanthaiah M Department of Anatomy, Basaveshwara Medical College, Chitradurga, Karnataka, India
  • Nagesh Raju G Department of Pharmacology, Wayanad Institute of Medical sciences, Wayanad Kerala, India
  • Lokanadham S Department of Anatomy, Santhiram Medical College and Hospital, Nandyal, Andhra Pradesh, India
  • Seshadri Reddy V Department of Biochemistry, Maheshwara Medical College and Hospital, Medak, Telangana, India


Eclipta Alba has been used in traditional and folklore medicine to treat Hyperlipidemia and hepatic disorders. The present study was aimed to investigate the Antihyperlipidemic and hepatoprotective potentials of Eclipta Alba in high-fat diet -induced Albino rats and to determine the underlying mechanism.  A total of 30 adult albino rats of Wistar strain weighing 165–215 g were utilized. Animals were treated with high-fat diet for 8 weeks followed by post-treatment of E. Alba for 1 week, 2 weeks, and 3 weeks, respectively. After 12 h of fasting on the last day of the experiment, serum blood samples were collected in EDTA vials and processed for biochemical analysis.  A significant decrease in levels of total cholesterol and triglycerides was noted on animals treated with E. alba compared to high-fat diet animals. Treatment of hypercholesterolemic rats with E. Alba showed a marked decrease of serum low-density lipoprotein (LDL) and very LDL cholesterol concentrations compared to the hypercholesterolemic rats. High-fat diet feeding worsened the levels of serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, and alkaline phosphatase enzymes, whereas the same markers were significantly improved by supplementation with E. alba compared to the normal group.  E. alba acts as an antihyperlipidemic agent in hyperlipidemic conditions and helps for better health.

Keywords: Serum, High-fat diet, Eclipta alba


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Satheesh Naik K, Gurushanthaiah M, Nagesh Raju G, Lokanadham S, & Seshadri Reddy V. (2019). Protective role of eclipta alba against hyperlipidemia induced by high-fat diet in albino rats. International Journal of Research in Pharmaceutical Sciences, 10(2), 1181-1184.
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