Biological evaluation of synthesised thiazolidinedione derivatives for anti-diabetic activity on STZ caused diabetes in rats

  • Geetha B Department of Pharmaceutical Science, Jawaharlal Nehru Technological University AnantapurAnantapuramu-515002, Andhra Pradesh, India
  • Swarnalatha G Department of Pharmaceutical Chemistry, Sri Venkateswara College of Pharmacy, RVS Nagar, Chit-toor - 517127
  • Subba Reddy GV Department of Chemistry, JNTUA College of Engineering (Autonomous), Pulivendula, YSR (Kadapa) dist, A.P, 516 390, India

Abstract

Diabetes Mellitus is the most common disease that poses a challenge to human health due to its secondary complications and resistance. Therefore, an attempt was made to synthesize novel compounds from thiazolidinedione moiety to treat the disease effectively and target diabetic complications. The synthesized compounds were tested for their physical parameters and characterised using NMR and IR spectra. They were also evaluated for STZ induced anti-diabetic activity in albino rats. The Compounds P5, II A8 and A9 were found effective in comparison with a standard drug, Pioglitazone. The other compounds were also effective but a reduction in activity is seen might be due to the inefficient binding to the PPAR receptors.

Keywords: Antidiabetic compounds, Thiazolidinediones, STZ induced diabetes

Downloads

Download data is not yet available.
Published
2019-04-14
Citations
How to Cite
Geetha B, Swarnalatha G, & Subba Reddy GV. (2019). Biological evaluation of synthesised thiazolidinedione derivatives for anti-diabetic activity on STZ caused diabetes in rats. International Journal of Research in Pharmaceutical Sciences, 10(2), 1042-1048. https://doi.org/10.26452/ijrps.v10i2.379
Section
Original Articles
Article Level Metrix
Abstract Views: 137
PDF Downloaded: 58