Effect of nanotization on therapeutic activities of biomolecules: Synthesis and Characterization

  • H.K. Kumara
  • K.R. Parikshith Gowda
  • D.M. Suyoga Vardhan
  • H. Pavan Kumar
  • D. Channe Gowda Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysuru - 570 006, Karnataka

Abstract

The bioactive organic nanoparticles were synthesized by precipitation-dialysis method from their corresponding bulk forms. The morphology and average particle size of the synthesized nanoparticles were characterized by scanning electron microscope (SEM) and dynamic light scattering (DLS) techniques. The nanotization decreases the particles size by 2-20 times with a narrow range of distribution and also considerable change in the shape. Further, the nanoparticles (1-10) and their bulk forms (1B-10B) were evaluated for in vitro antioxidant, anti-inflammatory and antimicrobial activities. The biological assay data revealed that new organic nanoparticles showed enhanced biological activity compared to their corresponding bulk forms. This may be due to increase in the surface area and decrease in the particles size after nanotization.

Article Level Metrics Total Count:    

Download data is not yet available.
Published
2017-06-21
How to Cite
KUMARA, H.K. et al. Effect of nanotization on therapeutic activities of biomolecules: Synthesis and Characterization. International Journal of Research in Pharmaceutical Sciences, [S.l.], v. 8, n. 2, p. 182-190, june 2017. ISSN 0975-7538. Available at: <https://www.pharmascope.org/index.php/ijrps/article/view/370>. Date accessed: 24 sep. 2017.
Section
Research Articles
Bookmark and Share