Lipid peroxidation and superoxide dismutase levels variation in type 2 dia-betes mellitus

  • Ashwin Kumar Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Velappanchavadi, Chennai -600077, Tamil Nadu, India
  • Ashok Vardhan N Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Velappanchavadi, Chennai -600077, Tamil Nadu, India
  • Savitha G Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Velappanchavadi, Chennai -600077, Tamil Nadu, India

Abstract

The long-term disorder which is characterised by the high blood sugar and insulin resistance is known as type 2 diabetes, and it is also known as diabetes mellitus type 2. Increased thirst, frequent urination, and unexplained weight loss are their common symptoms. Increased hunger, feeling tired, and sores that do not heal are also their symptoms. These symptoms occur slowly. 40 subjects were selected from the outpatient department of Saveetha Dental College and Hospitals. They were divided into two groups. Group I (Control group) – Normal healthy individuals – 20 in numbers Group II (Study group) – Type 2 Diabetes mellitus patients – 20 in numbers. 5ml of blood will be collected for the separation of serum. The serum was separated and analysed for Melanaldehyde and Superoxide dismutase by TBARS method and Pyrogallol Autoxidation method using ERBA CHEM 5 plus analyser. There is an increasing (MDA) which is very high in lipid peroxidation (p<0.001) as well as there is a significant decrease in (SOD) superoxide dismutase (p<0.005) in Hypothyroidism patients. In our findings its clearly understood that the Oxidative stress would get an increase in the diabetic people, this may lead to metabolic disease like dyslipidemia, Cardiac problems and renal failure etc.

Keywords: Diabetes mellitus, Antioxidants, Endocrine, Metabolic disorders, Endocrinopathy, Malanaldehyde, Superoxide dismutase, Pyrogallol Autoxidation

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Published
2018-07-12
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How to Cite
Ashwin Kumar, Ashok Vardhan N, & Savitha G. (2018). Lipid peroxidation and superoxide dismutase levels variation in type 2 dia-betes mellitus. International Journal of Research in Pharmaceutical Sciences, 9(3). Retrieved from https://www.pharmascope.org/index.php/ijrps/article/view/314
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Original Articles
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