Effect of acetazolamide on morphometry of Wistar rat foetus central nerv-ous system
Present study elucidates the relation between dose-related defects and morphometry of the central nervous system in Wistar rat foetus. Brain measurements of the dorsal surface of 16-20 days old pregnant Wistar rats foetuses were measured by using Vernier callipers. Adult pregnant rats were randomly divided into two groups. Control group received 0.25ml of normal saline and treatment group received 80 &160 mg/kg/b. Wt. of acetazolamide on 8th, 9th and 10th day of pregnancy respectively. Pregnancy was terminated on 16th, 18th, 20th day. All foetuses brain parameters were measured. Results show that high dose group rats were observed a significant reduction in all parameters when compared to control. Hence we can conclude that high doses may be neurotoxic to developing a nervous system of Wistar rats.
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