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Diabetes is considered as one of the main comorbidities linked to the severity of respiratory syndrome coronavirus 2. For people living with diabetes, even a minor illness can lead to dangerously high blood sugar levels. This may cause life-threatening complications, such as diabetic ketoacidosis or a hyperosmolar hyperglycaemic state. Literature has been found that 20–50% affected patients of COVID-19 pandemic are diabetic. Diabetic patients are highly affected due to increased viral entry into the cell, decrease immunity. Here are several hypotheses to explain the increased incidence and severity of COVID-19 infection in people with diabetes. Several cytokines are liberated in diabetics which can play a more deleterious role in Covid-19 infection. The severe acute respiratory syndrome (SARS)-CoV2, coronavirus pandemic highlights the importance of understanding shared disease pathophysiology, potentially informing therapeutic choices in individuals with Type 2 diabetes. Thus, knowledge about the potential mechanisms in between diabetes & the novel coronavirus is of utmost importance To managed diabetes, and individuals need to face challenges in the current trends in this pandemic crisis. For oral health professional, the management of diabetes should follow the protocol for the treatment of individuals with diabetes. This review illustrates the mechanisms by which diabetes modulates the host-viral interaction, host-immune responses and guidelines to manage during an illness.
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