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New series of four compounds was synthesized from multi hydroxyl group compounds such as methyl glycoside by coupling with long-chain alky propargyl ester ( C10, C12, C14 and unsaturated C18) via click chemistry after activation the hydroxyl at C6 position by chlorination with N-chlorosuccinimide NCS and functionalized with sodium azide NaN3. The chemical structures and the purity of the resulting triazoles derivatives was confirmed by elemental analysis (CHN) and spectroscopic analysis 1H NMR & 13C NMR. The biological activity for the target compounds was investigated, and they show good antibacterial and antifungal properties against some selected gram-posative and fungi, which make them suitable for medical applications.


Triazole ring click chemistry biological activity alkylation esterification

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How to Cite
Salih Mahdi Salman. (2019). Triazoles with long chain alkyl groups as a potential biological compounds. International Journal of Research in Pharmaceutical Sciences, 10(3), 2334-2341.