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Copper sulfide (CuS) nanoparticles have attracted increasing attention from biomedical researchers across the globe, because of their intriguing properties, which have been mainly explored for energy and catalysis related applications. The aim of the study is to prepare CuS NPs by BSA entrapment to reduce the toxicity, characterizing, comparative the toxicity before and after entrapment against bacteria and check the toxicity against RD and L20B cell lines. CuS-BSA NPs was an easy, low toxicity and low cost chemically synthesized. The CuS-BSA NPs was identified though UV-VIS spectrophotometer, FTIR, XRD, SEM, EDX, and Zeta potential. The antibacterial activity against different G-positive and G-negative bacterial strains have been investigated for (2 mg/ml) concentrations of CuS-BSA NPs and commercial CuS. A result showed that CuS-BSA NPs have more antibacterial activity than commercial CuS. Using different parameters of CuS-BSA NPs, its anti-cancer bioactivity for every compound synthesized in RD and L20B cell line was explored, and the result proved there was significant toxicity against RD and L20B cell lines.
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