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In our work, we are working with HIV genomes and AIDS proteins. In our method, we are performing sequence alignment using Needle man wunch algorithm of development and application the approach to calculate free energy and entropy by using the non-physical, chemical path through a thermodynamic series while the drug will interact with the protein. Here we are working on the principle-based on protein-protein, protein-peptide, protein-ligand, virtual screening and compulsory free energy estimation for HIV genomics and AIDS proteins. For sequence comparison, we are using the Needleman Wunsch algorithm. Proposed In our proposed work, we have taken the decision parameter is as binding energy to check the efficiency of the drug.
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