Transfersome vs liposomes as drug delivery vehicle for the treatment of skin cancers

  • Sivarajakumar Raahulan Department of Pharmaceutics, JSS College of Pharmacy, Ooty, India
  • Bharat Kumar Reddy Sanapalli Department of Pharmaceutics, JSS College of Pharmacy, Ooty, India
  • Sai Kiran SS. Pindiprolu Department of Pharmacology, JSS College of Pharmacy, Ooty, India
  • Veera Venkata Satyanarayana Reddy Karri Department of Pharmaceutics, JSS College of Pharmacy, Ooty, India

Abstract

Skin cancer is one of the leading causes of cancer-related deaths worldwide. It is estimated that by 2030, there will be around 13.1million deaths can occur due to skin cancer. Current treatment of skin cancer includes surgery, radiation and chemotherapy. Chemo-resistance, off-target effects and poor bioavailability are the major challenges for currently available drugs for the treatment of skin cancer. Transfersomes is a novel, elastic vesicular drug carrier composed of phospholipids, surfactants and ethanol for enhanced transdermal delivery. This article we have reviewed about merits/demerits, liposomes vs transfersomes, preparation methods, characterization, mechanism of skin delivery, and application and regulatory aspects of transfersomes in treating various skin cancers.

Keywords: Skin cancer, Melanoma, Transfersomes, Edge activator, Topical and Transdermal

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Published
2019-07-12
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How to Cite
Sivarajakumar Raahulan, Bharat Kumar Reddy Sanapalli, Sai Kiran SS. Pindiprolu, & Veera Venkata Satyanarayana Reddy Karri. (2019). Transfersome vs liposomes as drug delivery vehicle for the treatment of skin cancers. International Journal of Research in Pharmaceutical Sciences, 10(3), 1795-1807. https://doi.org/10.26452/ijrps.v10i3.1375
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Review Articles
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