Serological markers of autoimmunity ‎in women with polycystic ovary ‎syndrome

  • Wasan Wajdi Ibrahim Department of Obstetrics and Gynecology, College of Medicine,Baghdad ‎‎University, Iraq
  • Ekhlas Jabbar Kadhim Department of Obstetrics and Gynecology, College of Medicine,Baghdad ‎‎University, Iraq
  • Nada Saeed Abbas Department of Clinical Pharmacy‎, Baghdad Medical hospital, Ministry of Health, ‎‎Baghdad, ‎Iraq‎
  • Saba Ryadh ‎Younis Department of Obstetrics and Gynecology, College of Medicine,Baghdad ‎‎University, Iraq
  • Hayder Adnan Fawzi Department of Clinical Pharmacy‎, Baghdad Medical hospital, Ministry of Health, ‎‎Baghdad, ‎Iraq‎

Abstract

In the present study, we evaluate the serum level of common autoimmunologic markers in ‎women with polycystic ovary syndrome (PCOS) and study their relationship with ‎hormonal ‎parameters. The study was ‎an observational case-control study, done in a Tertiary referral hospital, the study ‎included ‎50 women with polycystic ovary syndrome and 50 matched control.‎ Serum levels of Antinuclear Antibody (ANA) and anti-double-stranded DNA (dsDNA) were significantly higher in polycystic ovary ‎syndrome women compared to control. Also, luteinizing hormone (LH), follicle stimulating hormone (FSH), and LH/FSH ratio were ‎significantly higher in polycystic ovary syndrome women compared to control. ‎dsDNA had excellent ability to differentiate PCOS from control (AUC=0.901) while ANA had good discrimination ability ‎‎(AUC=0.809). There was a significant direct relationship between ANA, dsDNA, and TSH ‎with FSH in PCOS women, ‏also a ‎significant direct relationship between ANA and TSH with LH, while ‎DsDNA did not correlate with LH. In conclusion, there is a clear relationship between immunological markers (ANA, dsDNA) with ‎‎polycystic ovary syndrome in various components of the disease, dsDNA offer better ability than ANA as a predictor of PCOS, indicating that dsDNA can be used as a non-invasive diagnostic tool for PCOS.

Keywords: ANA, DsDNA, hormone, polycystic ovary ‎syndrome

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Published
2019-07-12
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How to Cite
Wasan Wajdi Ibrahim, Ekhlas Jabbar Kadhim, Nada Saeed Abbas, Saba Ryadh ‎Younis, & Hayder Adnan Fawzi. (2019). Serological markers of autoimmunity ‎in women with polycystic ovary ‎syndrome. International Journal of Research in Pharmaceutical Sciences, 10(3), 1746-1750. https://doi.org/10.26452/ijrps.v10i3.1366
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Original Articles
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