Design, Synthesis of 4-hydroxy-2-phenyl-1-benzofuran-3(2H)-one derivatives as new leads for anti-cancer activity

  • Raghava Doonaboyina Department of Pharmaceutical Chemistry, Institute of Pharmacy, NIMS University, Jaipur, Rajasthan, India
  • Abhilasha Mittal Department of Pharmaceutical Chemistry, Institute of Pharmacy, NIMS University, Jaipur, Rajasthan, India
  • Sridhar Babu Gummadi Department of Pharmaceutical Chemistry, Institute of Pharmacy, NIMS University, Jaipur, Rajasthan, India

Abstract

Benzofuranone is a bicyclic ring where a benzene ring fused with a furanone. Computation chemistry plays a major role in the development of new lead molecules. The final compounds were obtained in multistep synthesis reactions using benzofuran-3-one derivatives as starting materials which were gained in various synthetic ways. Synthetic chemistry plays a major in developing a series of potent anti-cancer agents. Benzofuranone was synthesised by reacting benzene diols, and triols with bromo phenyl acetonitrile yielded an imine derivative are converted to a ketone with treatment with hydrochloric acid then cyclised with sodium acetate. Computational tools docking, virtual screening, ADMET prediction are utilised in the identification of new lead molecules. The compounds identity and purity were confirmed by spectral and analytical methods. Benzofuranone derivatives are screened antineoplastic activity was performed against human skin cancer cell line G361 at micro molecular concentrations. The compounds, IIB, IIC was found to be with potent activity.

Keywords: Docking, Virtual Screening, ADMET, Anti-cancer activity, Skin cancer, G361 cell line, Sulforhodamine assay

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Published
2019-01-05
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How to Cite
Raghava Doonaboyina, Abhilasha Mittal, & Sridhar Babu Gummadi. (2019). Design, Synthesis of 4-hydroxy-2-phenyl-1-benzofuran-3(2H)-one derivatives as new leads for anti-cancer activity. International Journal of Research in Pharmaceutical Sciences, 10(1), 748-760. Retrieved from https://www.pharmascope.org/index.php/ijrps/article/view/135
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