Antihyperglycemic effect of Portulaca pilosa Linn. in streptozotocin-induced diabetic rats

  • Arul Balasubramanian Department of Pharmacy Practice, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation (Deemed to be University), Salem-636 008, Tamil Nadu, India
  • Vijayarangan Sivasamy Department of Pharmacology, Trichy SRM Medical College Hospital and Research Centre, Tiruchirappalli-621105, Tamil Nadu, India
  • Manivannan Ekambaram Department of Pharmacology, Vinayaka Mission’s Kirupanandha Variyar Medical College and Hospitals, Vinayaka Mission’s Research Foundation (Deemed to be University), Seeragapadi Salem-636 308, Tamil Nadu, India
  • Kothai Ramalingam Department of Pharmacy Practice, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation (Deemed to be University), Salem-636 008, Tamil Nadu, India

Abstract

The antihyperglycemic activity of ethanolic extract of Portulaca pilosa Linn. was evaluated against streptozotocin-induced diabetic rats. The blood glucose levels were calculated at various time intervals of 0, 1, 2 and 3 h after the administration of ethanolic extract of P.pilosa. The ethanolic extract reduced the blood glucose levels significantly when it was administered at three doses of 100, 200 and 400 mg/kg. It reduces the blood glucose level from 334.67±5.27 to 134.57±6.49 at 3h after the administration of 200 mg/kg of ethanolic extract. The antihyperglycemic activity was evaluated in comparison of the administration of an oral hypoglycemic agent, Tolbutamide.

Keywords: Portulaca pilosa, Antihyperglycemic, Streptozotocin

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Published
2019-01-05
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How to Cite
Arul Balasubramanian, Vijayarangan Sivasamy, Manivannan Ekambaram, & Kothai Ramalingam. (2019). Antihyperglycemic effect of Portulaca pilosa Linn. in streptozotocin-induced diabetic rats. International Journal of Research in Pharmaceutical Sciences, 10(1), 673-676. Retrieved from https://www.pharmascope.org/index.php/ijrps/article/view/123
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Original Articles
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